Update on surgical treatment of pancreatic neuroendocrine neoplasms
نویسندگان
چکیده
منابع مشابه
PANCREATIC NEUROENDOCRINE NEOPLASMS (pNENs)
Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare lesions that have been increasing in incidence over the past few decades largely because of the diagnosis of pancreatic incidentalomas on cross-sectional imaging. Most of these tumors are nonfunctioning presenting with symptoms secondary to mass effect, metastatic disease or as incidental findings. Diagnostic workup aims to assess ...
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Pancreatic Endocrine Tumors (PNETs) represent a rare, but important subset of pancreatic neoplasms. These tumors account for 2–4% of all clinically detected pancreatic tumors. Their overall incidence is approximately 1 of 100 000 people per year [1,2]. PNETs consist of single or multiple benign or malignant neoplasms and are associated with multiple endocrine neoplasia type 1 (MEN1) in 10– 20% ...
متن کاملPancreatic carcinoids (serotonin-producing pancreatic neuroendocrine neoplasms)
INTRODUCTION Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare tumors representing 1% to 2% of all pancreatic neoplasms. These tumors can secrete a variety of biologically active substances giving rise to distinct clinical symptoms or can be clinically nonfunctioning. Apart from insulinomas and gastrinomas, which constitute the majority of functioning pNENs, some tumors may secret...
متن کاملSurgical Treatment of Liver Metastases in Neuroendocrine Neoplasms
Neuroendocrine neoplasms (NENs) are a distinctive entity, and nearly 10% of patients already have liver metastases at presentation. The management of neuroendocrine liver metastases (NEN-LM) is complex with differing patterns of metastatic presentation. An aggressive approach should be used to resect the primary tumor, to remove regional lymph nodes, and to resect or treat appropriate distant m...
متن کاملOn the value of Ki-67 in the prognostic grading of pancreatic neuroendocrine neoplasms: an update
In 1983, Gerdes, Schwab, Lemke and Stein reported upon a new monoclonal antibody which was generated by immunizing mice with nuclei of the Hodgkin lymphoma cell line L428. This antibody was found to label nuclei of proliferating cells including tumor cells. In their report the authors therefore concluded that “Ki-67 (a name derived from the city of Kiel where the authors worked, and the number ...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2014
ISSN: 1007-9327
DOI: 10.3748/wjg.v20.i38.13893